Leukemic transformation of Langerhans cell sarcoma.

Abstract

A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despite intensive chemotherapy, he died of disease progression 7 months after the initial diagnosis. Tumor cells in the leukemic phase expressed CD5, CD7, CD13, CD33, CD34, CD68, and CD123. These findings suggested leukemic transformation from Langerhans cell sarcoma. Leukemic transformation may be a clinical manifestation of advanced Langerhans cell sarcoma, and should be differentiated from acute myelogenous leukemia.

• Authors: Kousuke Sumida, Yuya Yoshidomi, Hiroko Koga, Nobuo Kuwahara, Eijo Matsuishi, Kennosuke Karube, Koichi Oshima, Hisashi Gondo
• Journal: International journal of hematology (Int J Hematol) Vol. 87 Issue 5 Pg. 527-531 (Jun 2008) ISSN: 0925-5710 [Print] Japan
• PMID: 18360746 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD

Topics

• Antigens, CD (immunology)
• Diagnosis, Differential
• Fatal Outcome
• Humans
• Immunophenotyping (methods)
• Langerhans Cell Sarcoma (immunology, pathology)
• Leukemia, Myeloid, Acute (immunology, pathology)
• Male
• Middle Aged