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Vitamin D endocrinology.

Abstract
Current status of our understanding of the metabolism of vitamin D and its implications in metabolic bone disease is reviewed. The details of metabolism of vitamin D3 to 25-hydroxyvitamin D3 in the liver and its further conversion in the kidneys to either 1,25-dihydroxyvitamin D3 or 24,25-dihydroxyvitamin D3 are presented. The latter conversions are regulated by the vitamin D status, serum calcium through the parathyroid gland system, and serum inorganic phosphorus concentration. The 1,25-dihydroxyvitamin D3 can now be regarded as a calcium- and a phosphate-mobilizing hormone and must be considered as one of the most important serum calcium-regulating hormones. Disruption of the vitamin D metabolic sequence or the signal system for 1,25-dihydroxyvitamin D3 results in several bone and calcium metabolism disorders such as renal osteodystrophy, hypoparathyroidism, pseudohypoparathyroidism, and vitamin D-dependency rickets. The use of the synthetic analogs of 1,25-dihydroxyvitamin D3 as well as 1,25-dihydroxyvitamin D3 itself in the management of these disease states is discussed.
AuthorsH F DeLuca
JournalAnnals of internal medicine (Ann Intern Med) Vol. 85 Issue 3 Pg. 367-77 (Sep 1976) ISSN: 0003-4819 [Print] United States
PMID183579 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Ergocalciferols
  • Phosphates
  • Vitamin D
  • Cholecalciferol
  • Calcium
Topics
  • Animals
  • Calcium (blood, metabolism)
  • Cholecalciferol (metabolism, physiology, therapeutic use)
  • Chronic Kidney Disease-Mineral and Bone Disorder (physiopathology)
  • Endocrine Glands (physiopathology)
  • Ergocalciferols (metabolism)
  • Homeostasis
  • Humans
  • Hyperparathyroidism, Secondary (physiopathology)
  • Intestinal Absorption
  • Kidney (enzymology)
  • Phosphates (blood)
  • Vitamin D (metabolism, physiology)

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