Abstract |
Current status of our understanding of the metabolism of vitamin D and its implications in metabolic bone disease is reviewed. The details of metabolism of vitamin D3 to 25-hydroxyvitamin D3 in the liver and its further conversion in the kidneys to either 1,25-dihydroxyvitamin D3 or 24,25-dihydroxyvitamin D3 are presented. The latter conversions are regulated by the vitamin D status, serum calcium through the parathyroid gland system, and serum inorganic phosphorus concentration. The 1,25-dihydroxyvitamin D3 can now be regarded as a calcium- and a phosphate-mobilizing hormone and must be considered as one of the most important serum calcium-regulating hormones. Disruption of the vitamin D metabolic sequence or the signal system for 1,25-dihydroxyvitamin D3 results in several bone and calcium metabolism disorders such as renal osteodystrophy, hypoparathyroidism, pseudohypoparathyroidism, and vitamin D-dependency rickets. The use of the synthetic analogs of 1,25-dihydroxyvitamin D3 as well as 1,25-dihydroxyvitamin D3 itself in the management of these disease states is discussed.
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Authors | H F DeLuca |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 85
Issue 3
Pg. 367-77
(Sep 1976)
ISSN: 0003-4819 [Print] United States |
PMID | 183579
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Ergocalciferols
- Phosphates
- Vitamin D
- Cholecalciferol
- Calcium
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Topics |
- Animals
- Calcium
(blood, metabolism)
- Cholecalciferol
(metabolism, physiology, therapeutic use)
- Chronic Kidney Disease-Mineral and Bone Disorder
(physiopathology)
- Endocrine Glands
(physiopathology)
- Ergocalciferols
(metabolism)
- Homeostasis
- Humans
- Hyperparathyroidism, Secondary
(physiopathology)
- Intestinal Absorption
- Kidney
(enzymology)
- Phosphates
(blood)
- Vitamin D
(metabolism, physiology)
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