Abstract |
Members of the CSF cytokine family play important roles in macrophage recruitment and activation. However, the role of M-CSF in pulmonary infection with Mycobacterium tuberculosis is not clear. In this study, we show the lungs of mice infected with M. tuberculosis displayed a progressive decrease in M-CSF in contrast to increasing levels of GM-CSF. Restoring pulmonary M-CSF levels during infection resulted in a significant decrease in the presence of foamy macrophages and increased expression of CCR7 and MHC class II, specifically on alveolar macrophages. In response to M-CSF, alveolar macrophages also increased their T cell-stimulating capacity and expression of DEC-205. These studies show that the levels of expression of M-CSF and GM-CSF participate in the progression of macrophages into foamy cells and that these cytokines are important factors in the differentiation and regulation of expression of dendritic cell-associated markers on alveolar macrophages. In addition, these studies demonstrate that M-CSF may have a role in the adaptive immune response to infection with M. tuberculosis.
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Authors | David M Higgins, Joaquin Sanchez-Campillo, Adrian G Rosas-Taraco, Jonathan R Higgins, Eric J Lee, Ian M Orme, Mercedes Gonzalez-Juarrero |
Journal | Journal of immunology (Baltimore, Md. : 1950)
(J Immunol)
Vol. 180
Issue 7
Pg. 4892-900
(Apr 01 2008)
ISSN: 0022-1767 [Print] United States |
PMID | 18354213
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Histocompatibility Antigens Class II
- Transforming Growth Factor beta
- Macrophage Colony-Stimulating Factor
- Interferon-gamma
- Granulocyte-Macrophage Colony-Stimulating Factor
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Topics |
- Animals
- Biomarkers
- CD4-Positive T-Lymphocytes
(immunology)
- Cell Count
- Cells, Cultured
- Chronic Disease
- Dendritic Cells
(immunology, metabolism)
- Disease Progression
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
(metabolism)
- Histocompatibility Antigens Class II
(immunology)
- Interferon-gamma
(metabolism)
- Lymphocyte Culture Test, Mixed
- Macrophage Colony-Stimulating Factor
(metabolism)
- Macrophages
(cytology, immunology, metabolism)
- Mice
- Mycobacterium tuberculosis
(immunology)
- Phenotype
- Sensitivity and Specificity
- Transforming Growth Factor beta
(metabolism)
- Tuberculosis
(immunology, metabolism, pathology)
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