Abstract |
Helicases are present in viruses, prokaryotes, and eukaryotes, and several of them have been linked to human diseases. Here we study the role of one putative DEAD-box RNA helicase, MrDb (DDX18), in tumor cells. We show that MrDb is a nucleolar protein ubiquitously expressed in tumor cells and that it is more abundantly expressed in proliferating cells. Inhibition of MrDb with dominant negative mutant or a shRNA reduces tumor cell proliferation without inducing a cell cycle arrest or apoptosis. These findings suggest that MrDb is important for cell proliferation and that its inhibition could prevent tumor cell proliferation.
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Authors | Sandy Dubaele, Patrick Chène |
Journal | Oncology research
(Oncol Res)
Vol. 16
Issue 12
Pg. 549-56
( 2007)
ISSN: 0965-0407 [Print] United States |
PMID | 18351129
(Publication Type: Journal Article)
|
Chemical References |
- RNA
- DDX18 protein, human
- DEAD-box RNA Helicases
|
Topics |
- Apoptosis
(physiology)
- Cell Cycle
(physiology)
- Cell Line, Tumor
- Cell Proliferation
- DEAD-box RNA Helicases
(metabolism)
- Drug Delivery Systems
- Gene Expression
(physiology)
- Humans
- Mutation
- RNA
(metabolism)
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