[Protective effect of 3-hydroxypyridine derivatives in extreme conditions].

The paper presents the results of experimental and clinical testing of 3-hydroxypyridine derivatives (emoxipin, mexidol and new compounds) various extreme conditions (hypoxia, hyper- and hypothermia, vibration, hypokinesia, ionizing and nonionizing radiation and others). Analysis of the results led to the conclusion that 3-hydroxipiridine derivatives are a group of compounds worthy of further in-depth investigations in a broad range of extreme conditions in order to assess their potential use in development of new medical protectors of humans and animals facing extreme factors of various nature.
AuthorsV V Iasnetsov
JournalAviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine (Aviakosm Ekolog Med) 2007 Nov-Dec Vol. 41 Issue 6 Pg. 5-12 ISSN: 0233-528X [Print] Russia (Federation)
PMID18350829 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Antioxidants
  • Picolines
  • Pyridines
  • mexidol
  • 3-hydroxypyridine
  • Anoxia (drug therapy, prevention & control)
  • Antioxidants (pharmacology, therapeutic use)
  • Brain (drug effects)
  • Brain Injuries (drug therapy)
  • Humans
  • Hypothermia (drug therapy)
  • Picolines (pharmacology, therapeutic use)
  • Pyridines (pharmacology, therapeutic use)

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