The
phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and
pyridine rings,
zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized.
Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with
dimethyl sulfate and
monochloroacetic acid to produce their quaternized products and
diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of
zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its
photodynamic therapy of
cancer (
PDT) efficacy by
cancer cell culture, the light exposed
dimethyl sulfate quaternized
zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence.