Abstract | BACKGROUND: METHODS: RESULTS: Two hundred and twenty-one patients were entered into the study, yielding 200 evaluable subjects. At-home emesis occurred in 15 (14.5%) of the 103 children who received ODT, and 31 (32%) of the 97 children in the placebo group, P = 0.004. Subgroup analysis demonstrated efficacy in patients who did not require rescue medication for nausea and vomiting while in the hospital, but did not demonstrate efficacy for patients who required rescue medication. CONCLUSIONS: At-home use of ODT may prevent emesis in children during the first 3 days after tonsillectomy in children. Patients who require rescue after prophylactic treatment for nausea and vomiting in the hospital may not respond to prophylactic ondansatron ODT at home.
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Authors | Peter J Davis, Kathleen M Fertal, Karen R Boretsky, Gina M Fedel, Michael D Ingram, Susan K Woelfel, Paul C Hoffmann, Harshad Gurnaney, Michael C Young |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 106
Issue 4
Pg. 1117-21, table of contents
(Apr 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18349181
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiemetics
- Placebos
- Tablets
- Ondansetron
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Topics |
- Adenoidectomy
(methods)
- Administration, Oral
- Antiemetics
(administration & dosage, therapeutic use)
- Child
- Double-Blind Method
- Humans
- Ondansetron
(administration & dosage, therapeutic use)
- Otorhinolaryngologic Surgical Procedures
(methods)
- Placebos
- Postoperative Complications
(epidemiology, prevention & control)
- Tablets
- Tonsillectomy
(methods)
- Vomiting
(epidemiology, prevention & control)
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