High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma.

Abstract	Paraneoplastic optic neuropathy (PON) is a rare syndrome usually associated with small cell lung carcinoma. In the 27 rigorously reported cases, neurologic manifestations other than visual loss have been present in all but 2. In the single case in which vision improved in response to treatment of the cancer, the collapsin response-mediating protein (CRMP)-5 titer did not change, and the ophthalmic examination was not detailed. We describe a patient with optic neuropathy and vitritis as the only clinical manifestations of PON marked by an extremely high titer of CRMP-5 antibody. Treatment of the underlying small cell lung cancer coincided with resolution of the visual abnormalities and a dramatic decrease in the CRMP-5 titer.
Authors	Edward Margolin, Andrew Flint, Jonathan D Trobe
Journal	Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society (J Neuroophthalmol) Vol. 28 Issue 1 Pg. 17-22 (Mar 2008) ISSN: 1536-5166 [Electronic] United States
PMID	18347453 (Publication Type: Case Reports, Journal Article)
Chemical References	Biomarkers, Tumor Microtubule-Associated Proteins Nerve Tissue Proteins Neural Cell Adhesion Molecules DPYSL5 protein, human Hydrolases
Topics	Aged Antineoplastic Combined Chemotherapy Protocols (therapeutic use) Biomarkers, Tumor (analysis, blood, immunology) Carcinoma, Small Cell (complications, radiotherapy) Female Humans Hydrolases Lung (pathology) Lung Neoplasms (complications, radiotherapy) Lymph Nodes (pathology) Microtubule-Associated Proteins Nerve Tissue Proteins (analysis, blood) Neural Cell Adhesion Molecules (analysis, metabolism) Optic Disk (immunology, pathology, physiopathology) Optic Nerve Diseases (blood, immunology, pathology) Paraneoplastic Syndromes, Nervous System (blood, pathology, physiopathology) Radiotherapy Retinal Artery (immunology, pathology, physiopathology) Tomography, X-Ray Computed Treatment Outcome Up-Regulation (drug effects, immunology) Vision, Low (blood, immunology, pathology) Vitreous Body (immunology, pathology, physiopathology)

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