Abstract |
Microsporidia are eukaryotic, obligate, intracellular protists that are emerging pathogens in immunocompromised hosts, including AIDS patients and organ transplant recipients. The efficacy of gamma interferon (IFN-gamma) for the treatment of microsporidiosis caused by Encephalitozoon cuniculi was studied by means of adoptive transfer and IFN-gamma administration in SCID mice. While the adoptive transfer of CD4(+) T cells from immunocompetent mice prolonged survival of SCID mice infected perorally with E. cuniculi, survival was not improved by adoptive transfer of CD4(+) T lymphocytes from IFN-gamma-deficient mice. The protective effect of IFN-gamma was confirmed in cytokine therapy experiments in which SCID mice receiving IFN-gamma survived significantly longer than mice receiving mock injections. The administration of serum containing specific antibodies against E. cuniculi was found to prolong the survival of concurrently IFN-gamma-treated SCID mice. The data presented in this study suggest that IFN-gamma is potentially useful as a cytokine therapy for microsporidiosis, especially in CD4(+) T-cell-deficient patients.
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Authors | Jirí Salát, Jirí Jelínek, Jindrich Chmelar, Jan Kopecky |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 52
Issue 6
Pg. 2169-74
(Jun 2008)
ISSN: 1098-6596 [Electronic] United States |
PMID | 18347109
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Interferon-gamma
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Topics |
- Adoptive Transfer
- Animals
- Antibodies, Monoclonal
(immunology, therapeutic use)
- Antibody Specificity
- CD4-Positive T-Lymphocytes
(immunology)
- Disease Models, Animal
- Encephalitozoon cuniculi
(immunology)
- Encephalitozoonosis
(immunology, mortality, parasitology, therapy)
- Humans
- Immunotherapy
- Interferon-gamma
(administration & dosage, genetics, therapeutic use)
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Mice, SCID
- Treatment Outcome
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