Abstract | BACKGROUND: Whereas allergy to vehicle ingredients (ie, excipients and preservatives) in topical steroid vehicles is well recognized, there are no data regarding which vehicle ingredients are in common use or on which vehicles and active molecules are associated with which ingredients. OBJECTIVE: To produce descriptive data on the use of allergenic vehicle ingredients in prescription topical corticosteroids. METHODS: The package insert for every steroid in widespread use in the United States was obtained from the manufacturer and used to generate an ingredient list for the product. RESULTS: CONCLUSIONS: Most prescription topical corticosteroids have the potential to cause allergic contact dermatitis owing to vehicle ingredients. Dermatologists should be aware of this possibility and should consider prescribing agents that do not contain potentially allergenic vehicle ingredients.
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Authors | Jacquelyn Coloe, Matthew J Zirwas |
Journal | Dermatitis : contact, atopic, occupational, drug
(Dermatitis)
2008 Jan-Feb
Vol. 19
Issue 1
Pg. 38-42
ISSN: 1710-3568 [Print] United States |
PMID | 18346395
(Publication Type: Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Hexoses
- Ointments
- Parabens
- Perfume
- Pharmaceutical Vehicles
- Solutions
- Thiazoles
- isothiazolidinone
- sorbitan sesquioleate
- Formaldehyde
- Propylene Glycol
- Lanolin
- Methyl Chloride
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Topics |
- Adrenal Cortex Hormones
(analysis, chemistry)
- Formaldehyde
(isolation & purification)
- Hexoses
(analysis)
- Lanolin
(isolation & purification)
- Methyl Chloride
(isolation & purification)
- Ointments
(analysis)
- Parabens
(isolation & purification)
- Perfume
(analysis, chemistry)
- Pharmaceutical Vehicles
(analysis, chemistry)
- Propylene Glycol
(analysis)
- Solutions
(analysis)
- Thiazoles
(isolation & purification)
- United States
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