Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS: About three times as many vacuoles were found in the type II fibres of tibialis anterioris muscle sections from K(+)-depleted rats as were found in the same muscle from normokalemic rats. In ex vivo experiments, a higher efflux of lactate on in vitro incubation was found in muscles of K(+)-depleted rats compared with that found in muscles from normokalemic rats. After treatment of K(+)-depleted rats with acetazolamide, the numbers of vacuoles in tibialis anterioris muscle decreased to near normal values. Incubation with acetazolamide in vitro inhibited efflux of lactate from muscles of K(+)-depleted rats. In contrast, bendroflumethiazide and dichlorphenamide failed to prevent vacuolar myopathy after treatment in vivo and failed to inhibit lactate efflux in vitro. CONCLUSIONS AND IMPLICATIONS:
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Authors | D Tricarico, S Lovaglio, A Mele, G Rotondo, E Mancinelli, G Meola, D C Camerino |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 154
Issue 1
Pg. 183-90
(May 2008)
ISSN: 0007-1188 [Print] England |
PMID | 18345024
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbonic Anhydrase Inhibitors
- Diuretics
- Electrolytes
- Lactic Acid
- Bendroflumethiazide
- Acetazolamide
- Dichlorphenamide
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Topics |
- Acetazolamide
(pharmacology)
- Animals
- Bendroflumethiazide
(pharmacology)
- Carbonic Anhydrase Inhibitors
(pharmacology)
- Cell Count
- Dichlorphenamide
(pharmacology)
- Diuretics
(pharmacology)
- Electrolytes
(blood)
- Lactic Acid
(metabolism)
- Male
- Muscle Fibers, Skeletal
(drug effects, pathology)
- Muscle, Skeletal
(drug effects, metabolism, pathology)
- Muscular Diseases
(etiology, pathology, prevention & control)
- Potassium Deficiency
(complications, pathology)
- Rats
- Rats, Wistar
- Vacuoles
(drug effects, pathology)
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