[Prognostic value of cyclin E and its relation to blood vessel invasion in rectal cancer].

Abstract

OBJECTIVE:

To investigate the expression of cyclin E in rectal carcinoma and its prognostic significance.

METHODS:

Cyclin E expression was examined by Western blotting in tumor tissue samples from 130 potentially resected rectal cancer patients with pathological stages I- III. Blood vessel invasion (BVI) was detected by immunohistochemistry. Multivariate analysis using the COX proportional hazards models was applied to evaluate the independent prognostic tumor markers of rectal cancer.

RESULTS:

The high expression rate of cyclin E in rectal carcinoma tissue was 23.1%(30/130). Except for a positive correlation with BVI and the gross configuration of tumor, the expression of cyclin E showed no significant relation to other clinicopathological factors. The 5-year disease-specific survival rate of cyclin E high expression group was 29.2%, which was significantly lower as compared to that of cyclin low expression group 70.5% (P<0.05). Multivariate analysis revealed that histology and cyclin E expression were independent prognostic indicators for rectal cancer patients at stages I- III. Compared to those with low expression levels, patients with high cyclin E levels had the hazard ratio (95%CI) for death from rectal cancer for 3.544 (1.528-8.215). In stage I- II, multivariate analysis showed that stronger predictive values of cyclin E expression even were detected. Patients with low cyclin E expression and negative BVI had a significantly better prognosis than those with high cyclin E expression and positive BVI.

CONCLUSIONS:

The expression of cyclin E is independent prognostic factor in rectal carcinoma at stages I- III. Detecting the expression of cyclin E and/or combined with BVI may help to predict clinical outcome and design further individualized intensive adjuvant treatment.

• Authors: Yong-Jian Zhou, Feng-Ling Wan, Li-Hua Yao, Li-Ya Feng
• Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery (Zhonghua Wei Chang Wai Ke Za Zhi) Vol. 11 Issue 2 Pg. 167-71 (Mar 2008) ISSN: 1671-0274 [Print] China
• PMID: 18344087 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclin E

Topics

• Adult
• Aged
• Aged, 80 and over
• Cyclin E (metabolism)
• Female
• Humans
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Neovascularization, Pathologic
• Prognosis
• Rectal Neoplasms (blood supply, metabolism, pathology)
• Survival Rate