Neuroprotective effects of T-817MA against noise-induced hearing loss.

Abstract

Oxidative stress, including reactive oxygen species and other free radicals, is thought to play an important role in neuronal cell death, including noise-induced hearing loss. 1-{3-[2-(1-Benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate (T-817MA), a novel neurotrophic agent, protects against oxidative stress-induced neurotoxicity. This study examines the effects of T-817MA in noise-induced ototoxicity in the cochlea. Guinea pigs received treatment with T-817MA-enhanced water (0.2, 0.7 mg/ml) or untreated water (control) beginning 10 days prior to noise exposure and continuing through this study. All subjects were exposed to 4-kHz octave-band noise at 120-dB SPL for 5h. Auditory thresholds were assessed by sound-evoked auditory brainstem response at 4, 8, and 16kHz, prior to and 10 days following noise exposure. Hair cell damage was analyzed by quantitative histology. T-817MA significantly reduced threshold deficits and hair cell death. These results suggest T-817MA reduces noise-induced hearing loss and cochlear damage, suggesting functional and morphological protection.

• Authors: Daisuke Yamashita, Akihiro Shiotani, Sho Kanzaki, Masaya Nakagawa, Kaoru Ogawa
• Journal: Neuroscience research (Neurosci Res) Vol. 61 Issue 1 Pg. 38-42 (May 2008) ISSN: 0168-0102 [Print] Ireland
• PMID: 18343519 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate
• Maleates
• Neuroprotective Agents
• Thiophenes

Topics

• Animals
• Cochlea (pathology)
• Evoked Potentials, Auditory, Brain Stem (physiology)
• Guinea Pigs
• Hair Cells, Auditory (pathology)
• Hearing Loss, Noise-Induced (prevention & control)
• Male
• Maleates (pharmacology)
• Neuroprotective Agents (pharmacology)
• Noise (adverse effects)
• Oxidative Stress (physiology)
• Thiophenes (pharmacology)