Effects of switching from topical beta-blockers to latanoprost on intraocular pressure in patients with normal-tension glaucoma.

Abstract

AIMS:

The effects of switching from topical beta-blockers (beta) to latanoprost (LA) on intraocular pressure (IOP) and IOP-reduction rate (IOP-RR) in patients with normal-tension glaucoma (NTG) were investigated.

SUBJECTS AND METHODS:

Sixty (60) NTG patients (60 eyes) were divided into three equal groups receiving carteolol hydrochloride (group A), nipradilol (group B), and betaxolol hydrochloride (group C) twice-daily for 3 months. The drugs were changed to topical LA administered once-daily for the next 3 months.

RESULTS:

Baseline IOP was 14.4 +/- 0.9, 14.6 +/- 0.6, and 14.6 +/- 0.9 mmHg in groups A, B, and C, respectively. At 3 months, IOP was 12.4 +/- 0.6, 13.4 +/- 0.6, and 12.9 +/- 0.8 mmHg and 10.5 +/- 0.5, 11.1 +/- 0.8, and 11.7 +/- 0.8 mmHg at 6 months in groups A, B, and C, respectively. At 3 months, IOP-RR was 10.4 +/- 5.5, 9.5 +/- 2.6, and 10.8 +/- 4.7% and 24.1 +/- 4.3, 22.9 +/- 5.9, and 19.4 +/- 3.8% at 6 months in groups A, B, and C, respectively. The groups did not significantly differ in the first 3 months regarding IOP and IOP-RR. Switching to LA significantly decreased IOP and increased IOP-RR in all groups.

CONCLUSION:

In NTG patients, LA reduced IOP more effectively than the beta tested.

• Authors: Yoko Ikeda, Kazuhiko Mori, Takeshi Ishibashi, Shigeta Naruse, Nobuko Nakajima, Shigeru Kinoshita
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 24 Issue 2 Pg. 230-4 (Apr 2008) ISSN: 1080-7683 [Print] United States
• PMID: 18341431 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Antihypertensive Agents
• Ophthalmic Solutions
• Propanolamines
• Prostaglandins F, Synthetic
• Latanoprost
• Carteolol
• nipradilol
• Betaxolol

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Antihypertensive Agents (pharmacology)
• Betaxolol (pharmacology)
• Carteolol (pharmacology)
• Female
• Glaucoma, Open-Angle (drug therapy, physiopathology)
• Humans
• Intraocular Pressure (drug effects)
• Latanoprost
• Male
• Middle Aged
• Ophthalmic Solutions
• Propanolamines (pharmacology)
• Prospective Studies
• Prostaglandins F, Synthetic (pharmacology)
• Time Factors