Abstract |
Cromakalim, a novel potassium channel-activating drug, was administered for a 3-day period in eight untreated hospitalized patients with established hypertension. The fixed and single dose of 1.5 mg/day produced a significant reduction in systolic and diastolic blood pressure with a small increase in heart rate. Glomerular filtration rate was unchanged and effective renal plasma flow was slightly increased with a concomitant small decrease in filtration fraction and in renal vascular resistance. No significant change was observed in urinary prostaglandin (PG)E2, PGF2 alpha, and thromboxane B2, while 6-keto-PGF1 alpha (the stable metabolite of prostacyclin) rose from 189 +/- 6 to 368 +/- 115 ng/day. The renal excretion of 6-keto-PGF1 alpha correlates with the modification observed in renal plasma flow, suggesting a compensatory role for prostacylin in preserving renal hemodynamics during antihypertensive therapy with cromakalim.
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Authors | M Lebel, J H Grose, Y Lacourcière |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 4
Issue 9
Pg. 740-4
(Sep 1991)
ISSN: 0895-7061 [Print] United States |
PMID | 1834087
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antihypertensive Agents
- Benzopyrans
- Chlorides
- Eicosanoids
- Prostaglandins
- Pyrroles
- Cromakalim
- Thromboxane B2
- Atrial Natriuretic Factor
- Sodium
- Dinoprost
- Dinoprostone
- Potassium
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Topics |
- Adult
- Antihypertensive Agents
(administration & dosage, pharmacology)
- Atrial Natriuretic Factor
(blood)
- Benzopyrans
(administration & dosage, pharmacology)
- Blood Pressure
(drug effects, physiology)
- Chlorides
(blood)
- Cromakalim
- Dinoprost
(urine)
- Dinoprostone
(urine)
- Eicosanoids
(urine)
- Female
- Glomerular Filtration Rate
(drug effects)
- Heart Rate
(drug effects, physiology)
- Hemodynamics
(drug effects, physiology)
- Humans
- Hypertension
(physiopathology, urine)
- Kidney
(drug effects, metabolism, physiology)
- Male
- Middle Aged
- Potassium
(blood)
- Prostaglandins
(urine)
- Pyrroles
(administration & dosage, pharmacology)
- Regional Blood Flow
(drug effects)
- Renin-Angiotensin System
(drug effects, physiology)
- Sodium
(blood)
- Thromboxane B2
(urine)
- Time Factors
- Vascular Resistance
(drug effects, physiology)
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