Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: Oral glucose tolerance test (OGTT) and venous 24-h glucose- insulin profile were performed yearly from adolescence. RESULTS: Patient 1 (now aged 31 years) developed insulin-dependent diabetes at the age of 25 years. In patient 2 (now aged 17 years), impaired fasting glucose and a diabetic OGTT response with normal A1C values have been observed since the age of 10 years. In patient 3 (now aged 24 years), intolerant OGTT response and hyperglycemic episodes with normal A1C have been observed since the age of 16 years. All patients presented relatively low insulin levels during hyperglycemia, normal BMI, and negative autoantibodies (GAD antibody, insulinoma-associated protein 2, and islet cell antibody). CONCLUSIONS:
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Authors | Miquel Gussinyer, María Clemente, Rocio Cebrián, Diego Yeste, Marian Albisu, Antonio Carrascosa |
Journal | Diabetes care
(Diabetes Care)
Vol. 31
Issue 6
Pg. 1257-9
(Jun 2008)
ISSN: 1935-5548 [Electronic] United States |
PMID | 18339976
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- ATP-Binding Cassette Transporters
- Insulin
- Potassium Channels, Inwardly Rectifying
- Receptors, Drug
- Sulfonylurea Receptors
|
Topics |
- ATP-Binding Cassette Transporters
(genetics)
- Adolescent
- Adult
- Child
- Congenital Hyperinsulinism
(genetics)
- Follow-Up Studies
- Glucose Intolerance
(genetics)
- Glucose Tolerance Test
- Humans
- Infant
- Insulin
(blood)
- Male
- Mutation
- Potassium Channels, Inwardly Rectifying
(genetics)
- Receptors, Drug
(genetics)
- Sulfonylurea Receptors
|