Abstract | OBJECTIVE: DESIGN: Prospective observational study. SETTING: Gynecology department in a teaching hospital. PATIENT(S): Hyperandrogenic women presenting for hirsutism treatment were followed between January 2000 and January 2007. INTERVENTION(S): MAIN OUTCOME MEASURE(S): Adverse events, safety, tolerability and efficacy were assessed every 6 months during the follow-up. Liver and lipid profiles were also recorded. RESULT(S): Patients under flutamide therapy showed, compared with basal values, a significant progressive decrease in hirsutism scores after 6 months of treatment with a maximum effect at 12 months that was maintained during the 84 months of follow-up. A total of 40.96% women presented one or more adverse effects during the follow-up; 33.73% showed at least one adverse effect possibly related with the study drug, and 24.09% withdrew from the study because of adverse effects. During the follow-up, as many as 59% of patients abandoned the study. CONCLUSION(S):
Flutamide is very effective for hirsutism treatment; however, adverse effects are very frequent and associated with low long-term compliance.
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Authors | Camil Castelo-Branco, Dolores Moyano, Olga Gómez, Juan Balasch |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 91
Issue 4
Pg. 1183-8
(Apr 2009)
ISSN: 1556-5653 [Electronic] United States |
PMID | 18339379
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Androgen Antagonists
- Contraceptives, Oral, Hormonal
- Ethinyl Estradiol
- Flutamide
- Desogestrel
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Topics |
- Adult
- Androgen Antagonists
(adverse effects, therapeutic use)
- Contraceptives, Oral, Hormonal
(administration & dosage, adverse effects)
- Desogestrel
(administration & dosage, adverse effects)
- Ethinyl Estradiol
(administration & dosage, adverse effects)
- Female
- Flutamide
(administration & dosage, adverse effects, therapeutic use)
- Follow-Up Studies
- Hirsutism
(drug therapy)
- Humans
- Time Factors
- Treatment Outcome
- Young Adult
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