Abstract | PURPOSE: To identify and mathematically model molecular predictors of response to the enediyne chemotherapeutic agent, neocarzinostatin, in nervous system cancer cell lines. METHODS: RESULTS: In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.9; P < 0.01). Neuroblastoma and brain tumor cell lines are particularly sensitive to neocarzinostatin; the sensitivity of brain tumor lines to neocarzinostatin is enhanced by transfection with an expression construct for Bcl-2 and is proportional in transfected cells to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.7). CONCLUSION: These studies underscore the potential of molecular profiling in identifying effective chemotherapeutic paradigms for cancer in general and tumors of the nervous system in particular.
|
Authors | Danny Rogers, Karen D Nylander, Zhiping Mi, Tong Hu, Nina F Schor |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 62
Issue 4
Pg. 699-706
(Sep 2008)
ISSN: 0344-5704 [Print] Germany |
PMID | 18338171
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Antibiotics, Antineoplastic
- Biomarkers, Tumor
- Proto-Oncogene Proteins c-bcl-2
- Zinostatin
- Caspase 3
|
Topics |
- Antibiotics, Antineoplastic
(pharmacology)
- Biomarkers, Tumor
(metabolism)
- Caspase 3
(metabolism)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Drug Resistance
(drug effects)
- Drug Screening Assays, Antitumor
- Gene Expression Profiling
- Glioma
(drug therapy, metabolism, pathology)
- Humans
- Medulloblastoma
(drug therapy, metabolism, pathology)
- Nervous System Neoplasms
(drug therapy, metabolism, pathology)
- Neuroblastoma
(drug therapy, metabolism, pathology)
- Predictive Value of Tests
- Proto-Oncogene Proteins c-bcl-2
(genetics, metabolism)
- Zinostatin
(pharmacology)
|