Abstract | BACKGROUND: METHODS: RESULTS: The CG injections resulted in a thicker peritoneal membrane, reflecting peritoneal fibrosis with accumulation of interstitial type I collagen, peritoneal deposition of lipid peroxidation products (4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal), and an elevated level of 8-hydroxy-2'-deoxyguanosine in peritoneal fluid in both mouse groups on day 14. The extent of these changes, however, was significantly higher in acatalasemic mice than in wild-type mice. The level of catalase activity remained low in the acatalasemic peritoneum without the compensatory upregulation of glutathione peroxidase, but with an insufficient upregulation of superoxide dismutase activity in CG-injected mice. CONCLUSIONS:
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Authors | Naomi Fukuoka, Hitoshi Sugiyama, Tatsuyuki Inoue, Yoko Kikumoto, Kei-ichi Takiue, Hiroshi Morinaga, Kazushi Nakao, Yohei Maeshima, Masato Asanuma, Da-Hong Wang, Keiki Ogino, Noriyoshi Masuoka, Hirofumi Makino |
Journal | American journal of nephrology
(Am J Nephrol)
Vol. 28
Issue 4
Pg. 661-8
( 2008)
ISSN: 1421-9670 [Electronic] Switzerland |
PMID | 18337633
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2008 S. Karger AG, Basel. |
Chemical References |
- Oxidants
- Catalase
- Deoxyguanosine
- Chlorhexidine
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Topics |
- Acatalasia
(complications)
- Animals
- Ascitic Fluid
(chemistry)
- Catalase
(blood, physiology)
- Chlorhexidine
- Deoxyguanosine
(analysis)
- Fibrosis
(chemically induced, etiology)
- Immunohistochemistry
- Lipid Peroxidation
- Male
- Mice
- Mice, Mutant Strains
- Oxidants
(toxicity)
- Peritoneal Dialysis
(adverse effects)
- Peritoneum
(drug effects, pathology)
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