Abstract | OBJECTIVES: METHODS: Twenty-two New Zealand white rabbits were divided into three groups. All three groups, including the ischemia-reperfusion group (IR, n = 8), underwent 45 min of infrarenal aortic occlusion. The early treatment group (early, n = 8) received 0.06 mug/kg/min of ATL-146e for 3 h beginning 10 min prior to reperfusion. The delayed treatment group (delayed, n = 6) received ATL-146e starting 1 h after reperfusion. After 48 h, hind limb function was graded using the Tarlov score. Finally, lumbar spinal cord neuronal cytoarchitecture was evaluated. RESULTS: Hemodynamic parameters were similar among the groups. Hind limb function at 48 h was significantly better in the early group (3.5 +/- 1.0) compared to the IR group (0.625 +/- 0.5, P < or = 0.01). There was a trend towards better hind limb function in the early group compared to the delayed group (2.4 +/- 1.1, P = 0.08). Hind limb function was similar between delayed and IR groups. Hematoxylin- eosin spinal cord sections demonstrated preservation of viable motor neurons in the early group compared to the delayed and IR groups. CONCLUSIONS:
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Authors | T Brett Reece, Curtis G Tribble, David O Okonkwo, Jonathon D Davis, Thomas S Maxey, Leo M Gazoni, Joel Linden, Irving L Kron, John A Kern |
Journal | Journal of cardiovascular medicine (Hagerstown, Md.)
(J Cardiovasc Med (Hagerstown))
Vol. 9
Issue 4
Pg. 363-7
(Apr 2008)
ISSN: 1558-2027 [Print] United States |
PMID | 18334890
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- ATL 146e
- Cyclohexanecarboxylic Acids
- Purines
- Receptor, Adenosine A2A
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Topics |
- Analysis of Variance
- Animals
- Cyclohexanecarboxylic Acids
(pharmacology)
- Disease Models, Animal
- Hemodynamics
- Purines
(pharmacology)
- Rabbits
- Receptor, Adenosine A2A
- Recovery of Function
(drug effects)
- Reperfusion Injury
(drug therapy, pathology)
- Spinal Cord
(blood supply, pathology)
- Statistics, Nonparametric
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