Abstract |
The efficacy of rifalazil and other benzoxazinorifamycins was tested in a mouse model of lung infection against Chlamydia pneumoniae. Rifalazil and six related new chemical entities all showed efficacy after one dose per day for 3 days at either 3 or 1 mg/kg of body weight.
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Authors | Lee Ann Campbell, Cho-Chou Kuo, Robert J Suchland, David M Rothstein |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 52
Issue 5
Pg. 1855-8
(May 2008)
ISSN: 1098-6596 [Electronic] United States |
PMID | 18332169
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Rifamycins
- KRM 1648
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Topics |
- Animals
- Anti-Bacterial Agents
(pharmacology)
- Chlamydia Infections
(drug therapy)
- Chlamydophila pneumoniae
(drug effects)
- Disease Models, Animal
- Lung
(drug effects, microbiology)
- Male
- Mice
- Microbial Sensitivity Tests
- Rifamycins
(pharmacology)
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