(S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat.

Abstract

The 5-HT1A-receptor antagonist (S)-UH-301 (S)-5-fluoro-8-hydroxy-2- (dipropylamino)tetralin) completely antagonized the hypotension and bradycardia induced by (R) = 8-OH DPAT [R)-8-hydroxy-2- (dipropylamino)tetralin) in conscious rats. (S)-UH-301 alone induced a weak hypertension, which might be due to its 5-HT1A-receptor antagonistic properties. (R)-UH-301 induced effects similar to those of (R)-8-OH DPAT, i.e., a short initial phase of hypertension followed by a long-lasting hypotension and bradycardia. Thus, (R)-UH-301 behaves as a 5-HT1A-receptor agonist and (S)-UH-301 as a 5-HT1A-receptor antagonist, abolishing the effects induced by (R)-8-OH DPAT.

• Authors: L Björk, S Lindgren, U Hacksell, T Lewander
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 199 Issue 3 Pg. 367-70 (Jul 09 1991) ISSN: 0014-2999 [Print] Netherlands
• PMID: 1833212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Serotonin Antagonists
• Tetrahydronaphthalenes
• UH 301
• Sodium Chloride
• 8-Hydroxy-2-(di-n-propylamino)tetralin

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin
• Animals
• Cardiovascular System (drug effects)
• Consciousness
• Male
• Rats
• Rats, Inbred Strains
• Serotonin Antagonists (pharmacology)
• Sodium Chloride (pharmacology)
• Stereoisomerism
• Tetrahydronaphthalenes (antagonists & inhibitors, pharmacology)