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Loss of leucocyte common antigen (CD45) on atypical lymphocytes in the localized but not disseminated type of Pagetoid reticulosis.

Abstract
Atypical intraepidermal T cells in Pagetoid reticulosis did not express CD45RO, the low molecular isoform of CD45. These cells did express other CD45 isoforms in the disseminated aggressive variant (Ketron-Goodman type). The complete CD45 family was lost from the cell surface in the benign localized variant (Woringer-Kolopp type). Because the presence of CD45 is crucial for the function of the lymphocyte-specific tyrosine kinase p56lck, which is associated with lymphocyte growth and transformation, this may be the molecular basis for the non-aggressive nature of this clonal T-cell proliferation.
AuthorsW Sterry, A Hauschild
JournalThe British journal of dermatology (Br J Dermatol) Vol. 125 Issue 3 Pg. 238-42 (Sep 1991) ISSN: 0007-0963 [Print] ENGLAND
PMID1832931 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD
  • Histocompatibility Antigens
  • Antigens, CD45
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD (analysis)
  • Antigens, CD45
  • Epidermis (immunology)
  • Female
  • Histocompatibility Antigens (analysis)
  • Humans
  • Immunoenzyme Techniques
  • Lymphoproliferative Disorders (immunology)
  • Male
  • Middle Aged
  • Skin (immunology)
  • Skin Diseases (immunology)
  • T-Lymphocytes (immunology)

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