Loss of leucocyte common antigen (CD45) on atypical lymphocytes in the localized but not disseminated type of Pagetoid reticulosis.

Atypical intraepidermal T cells in Pagetoid reticulosis did not express CD45RO, the low molecular isoform of CD45. These cells did express other CD45 isoforms in the disseminated aggressive variant (Ketron-Goodman type). The complete CD45 family was lost from the cell surface in the benign localized variant (Woringer-Kolopp type). Because the presence of CD45 is crucial for the function of the lymphocyte-specific tyrosine kinase p56lck, which is associated with lymphocyte growth and transformation, this may be the molecular basis for the non-aggressive nature of this clonal T-cell proliferation.
AuthorsW Sterry, A Hauschild
JournalThe British journal of dermatology (Br J Dermatol) Vol. 125 Issue 3 Pg. 238-42 (Sep 1991) ISSN: 0007-0963 [Print] ENGLAND
PMID1832931 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD
  • Histocompatibility Antigens
  • Antigens, CD45
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD (analysis)
  • Antigens, CD45
  • Epidermis (immunology)
  • Female
  • Histocompatibility Antigens (analysis)
  • Humans
  • Immunoenzyme Techniques
  • Lymphoproliferative Disorders (immunology)
  • Male
  • Middle Aged
  • Skin (immunology)
  • Skin Diseases (immunology)
  • T-Lymphocytes (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: