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Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).

Abstract
Bioassay-guided fractionation of extracts of various plants, marine organisms, and microorganisms has led to the discovery of new natural sources of a number of known compounds that have significant biological activity. The isolation of interesting and valuable cancer cell growth inhibitors including majusculamide C ( 1), axinastatin 5 ( 5), bengazoles A ( 6), B ( 7), and E ( 8), manzamine A ( 10), jaspamide ( 11), and neoechinulin A ( 19) has been summarized.
AuthorsGeorge R Pettit, Fiona Hogan, Jun-Ping Xu, Rui Tan, Toshihiko Nogawa, Zbigniew Cichacz, Robin K Pettit, Jiang Du, Qing-Hua Ye, Gordon M Cragg, Cherry L Herald, Michael S Hoard, Animesh Goswami, Justin Searcy, Larry Tackett, Dennis L Doubek, Lee Williams, John N A Hooper, Jean M Schmidt, Jean-Charles Chapuis, Denise N Tackett, Felicia Craciunescu
JournalJournal of natural products (J Nat Prod) Vol. 71 Issue 3 Pg. 438-44 (Mar 2008) ISSN: 0163-3864 [Print] United States
PMID18327911 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Carbazoles
  • Depsipeptides
  • Indole Alkaloids
  • Oxazoles
  • Peptides, Cyclic
  • Piperazines
  • axinastatin 5
  • bengazole A
  • bengazole B
  • bengazole E
  • neoechinulin A
  • jasplakinolide
  • manzamine A
  • majusculamide C
Topics
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Carbazoles (chemistry, isolation & purification, pharmacology)
  • Depsipeptides (chemistry, isolation & purification, pharmacology)
  • Drug Screening Assays, Antitumor
  • Indole Alkaloids (chemistry, isolation & purification, pharmacology)
  • Marine Biology
  • Molecular Structure
  • Oxazoles (chemistry, isolation & purification, pharmacology)
  • Peptides, Cyclic (chemistry, isolation & purification, pharmacology)
  • Piperazines (chemistry, isolation & purification, pharmacology)

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