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Interferon-beta therapy for malignant melanoma: the dose is crucial for inhibition of proliferation and induction of apoptosis of melanoma cells.

Abstract
We investigated the anti-tumor effect of human interferon-beta (HuIFN-beta) against malignant melanoma. In vitro study revealed that HuIFN-beta not only inhibited proliferation of melanoma cells (seven cell lines: MM-AN, MM-BP, MM-LH, MM-RU, PM-WK, RPM-EP, RPM-MC) but also induced apoptosis in a dose dependent fashion, though the sensitivity to HuIFN-beta was different among cell lines. In addition, we administered HuIFN-beta into cutaneous metastatic lesions of melanoma and evaluated clinical and histopathological effects. Although the size of the metastatic cutaneous lesion did not change by the intralesional injection of HuIFN-beta, histopathological examination revealed apoptotic changes of melanoma cells along with dense lymphohistiocytic infiltration. The present study confirmed direct and indirect inhibitory effects of HuIFN-beta on human melanoma cells and suggests that local higher concentration of HuIFN-beta is needed to eradicate melanoma lesions.
AuthorsHitomi Kubo, Atsuko Ashida, Kazuhiko Matsumoto, Toshiro Kageshita, Akifumi Yamamoto, Toshiaki Saida
JournalArchives of dermatological research (Arch Dermatol Res) Vol. 300 Issue 6 Pg. 297-301 (Jul 2008) ISSN: 1432-069X [Electronic] Germany
PMID18324409 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon-beta
Topics
  • Apoptosis (drug effects, immunology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Dose-Response Relationship, Drug
  • Down-Regulation
  • Humans
  • Immunotherapy
  • Injections, Intralesional
  • Interferon-beta (pharmacology, therapeutic use)
  • Melanoma (drug therapy, pathology)
  • Neoplasm Metastasis
  • Skin Neoplasms (drug therapy, pathology)
  • Vaccination

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