[Efficacy of adipin and normodipin (generic drugs of amlodipine) vs norvsc in treatment of essential hypertension].

Abstract

It's well known, that norvsc - a very effective and popular cardiovascular medication - has many generic analogs. The reason of our study was to compare the efficacy and safety of adipin ("GMP", Georgia), normodipin ("Gedeon Richter", Hungary) and norvasc ("Pfizer", USA) in patients with essential hypertension (stage I-II, JNC VII). The study was performed using ambulatory blood pressure monitoring (ABPM), the data from which closely correlate with end-organ damage in hypertension and provides excellent information about hypotensive drug effect on the circadian rhythm of blood pressure and its adequate control. It was open liable, crossover, comparative, prospective trial in 20 patients. Our data confirm that generic drugs adipin and normodipine are as effective and safe as original norvasc in treatment of patients with hypertension.

• Authors: B Tsinamdzgvrishvili, D Trapaidze, N Loladze, A Rekhviashvili
• Journal: Georgian medical news (Georgian Med News) Issue 154 Pg. 14-7 (Jan 2008) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 18323585 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Calcium Channel Blockers
• Drugs, Generic
• Amlodipine

Topics

• Amlodipine (therapeutic use)
• Calcium Channel Blockers (therapeutic use)
• Cross-Over Studies
• Drugs, Generic
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged
• Treatment Outcome