Abstract | BACKGROUND AND PURPOSE: METHODS: A case control methodology using a UK stroke cohort (872 cases, 933 controls) was adopted, with additional 5-lipoxygenase activating protein genotyping and replication of positive findings undertaken in an independent stroke population from Germany (601 cases, 736 controls). RESULTS: CONCLUSIONS: Genetic variation in leukotriene pathway members and their receptors confer an increased risk of ischemic stroke in 2 independent populations. These risks show different magnitudes depending on ischemic stroke subtype.
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Authors | Steve Bevan, Martin Dichgans, H Erich Wiechmann, Andreas Gschwendtner, Thomas Meitinger, Hugh S Markus |
Journal | Stroke
(Stroke)
Vol. 39
Issue 4
Pg. 1109-14
(Apr 2008)
ISSN: 1524-4628 [Electronic] United States |
PMID | 18323512
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 5-Lipoxygenase-Activating Proteins
- ALOX5AP protein, human
- Carrier Proteins
- LTB4R protein, human
- LTB4R2 protein, human
- Leukotrienes
- Membrane Proteins
- Receptors, Leukotriene B4
- Epoxide Hydrolases
- leukotriene A4 hydrolase
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Topics |
- 5-Lipoxygenase-Activating Proteins
- Aged
- Aged, 80 and over
- Brain Ischemia
(epidemiology, genetics)
- Carrier Proteins
(genetics, metabolism)
- Cohort Studies
- Epoxide Hydrolases
(genetics, metabolism)
- Female
- Genetic Predisposition to Disease
(epidemiology)
- Genetic Variation
- Haplotypes
- Humans
- Leukotrienes
(biosynthesis)
- Male
- Membrane Proteins
(genetics, metabolism)
- Middle Aged
- Receptors, Leukotriene B4
(genetics, metabolism)
- Risk Factors
- Stroke
(epidemiology, genetics)
- United Kingdom
(epidemiology)
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