HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Severe liver disease in pregnancy.

AbstractOBJECTIVE:
To determine the clinical characteristics of patients with fulminant hepatitis of pregnancy (FHP) and acute fatty liver of pregnancy (AFLP) and analyze their correlation with pregnancy outcome.
METHODS:
Of 55 pregnant women with severe liver disease, 41 had FHP and 14 had AFLP.
RESULTS:
Jaundice was the primary manifestation for both FHP and AFLP and hepatic encephalopathy was the most significant complication for both. Disseminated intravascular coagulation, albuminuria, and prothrombin activity were found to be independent risk factors of maternal mortality for both. However, the rates of preterm labor, fetal demise, and neonatal asphyxia were lower in the FHP group.
CONCLUSION:
Women with FHP or AFLP are at risk for severe complications and adverse pregnancy outcome. Since the 2 conditions are managed differently, early diagnosis is essential.
AuthorsHui Chen, Li Yuan, Jianping Tan, Yukun Liu, Jianping Zhang
JournalInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 101 Issue 3 Pg. 277-80 (Jun 2008) ISSN: 0020-7292 [Print] United States
PMID18321514 (Publication Type: Journal Article)
Topics
  • Acute Disease
  • Adolescent
  • Adult
  • Fatty Liver (complications, mortality)
  • Female
  • Fetal Death
  • Hepatic Encephalopathy (etiology, pathology)
  • Humans
  • Jaundice (etiology)
  • Liver (physiopathology)
  • Liver Failure, Acute (complications, mortality)
  • Maternal Mortality
  • Pregnancy
  • Pregnancy Complications (diagnosis, etiology)
  • Pregnancy Outcome
  • Regression Analysis
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: