Abstract | CONTEXT: As we write, novel antibodies that may well alter the routine practice of surgical neuropathology are in development, characterization, and the early stages of clinical use. These will be used for purposes of tumor subclassification, as prognostic markers, as identifiers of potential therapeutic targets, and as predictors of treatment response. OBJECTIVE: To provide for nonspecialists a critical assessment of the peer-reviewed literature (necessarily colored by our own experience) as it pertains to several immunohistochemical reagents that have been recently forwarded as adjuncts to the histologic typing of central nervous system tumors. DATA SOURCES: We address in these pages only antibodies that are commercially available, that have been the subjects of multiple published series, and that we have had occasion to use in the course of everyday problem solving. CONCLUSIONS:
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Authors | Mark A Edgar, Marc K Rosenblum |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 132
Issue 3
Pg. 500-9
(Mar 2008)
ISSN: 1543-2165 [Electronic] United States |
PMID | 18318590
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Biomarkers, Tumor
(analysis)
- Central Nervous System Neoplasms
(diagnosis)
- Diagnosis, Differential
- Humans
- Immunohistochemistry
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