[Analysis of changes in the accumulation of the photosensitizer Photosens, its elimination kinetics and distribution in the tissues of the eye and eyelids in health and in some tumorous processes].

Abstract

The authors analyze and present the results of spectroscopic studies into changes in the accumulation of the photosensitizer Photosens, its elimination kinetics and distribution in the tissues of the eye and eyelids, as well as in the tumors that have developed at these sites. The findings allowed the authors to estimate the duration of the agent's persistence in the eye tissues and the time interval associated with the high risk for phototoxic eyelid skin and conjunctival reactions and to determine a possibility of and conditions for photodynamic therapy, as well as the length of hospital stay when the latter was performed.

• Authors: V G Likhvantseva, E A Osipova, M A Petrenko, O Iu Merzliakova, S G Kuz'min, G N Vorozhtsov
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 2008 Jan-Feb Vol. 124 Issue 1 Pg. 38-44 ISSN: 0042-465X [Print] Russia (Federation)
• PMID: 18318209 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Indoles
• Organometallic Compounds
• Radiation-Sensitizing Agents
• aluminum tetrasulfophthalocyanine

Topics

• Conjunctiva (metabolism)
• Conjunctival Neoplasms (diagnosis, drug therapy, metabolism)
• Diagnosis, Differential
• Eyelid Neoplasms (diagnosis, drug therapy, metabolism)
• Eyelids (metabolism)
• Humans
• Indoles (pharmacokinetics, therapeutic use)
• Organometallic Compounds (pharmacokinetics, therapeutic use)
• Radiation-Sensitizing Agents (pharmacokinetics, therapeutic use)
• Spectrometry, Fluorescence
• Treatment Outcome