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First-trimester maternal serum progesterone in aneuploid pregnancies.

AbstractBACKGROUND:
First-trimester maternal serum screening for Down syndrome (DS) can be improved by the use of additional serum markers. We examined whether progesterone (P), synthesized by placenta, might be a first-trimester maternal serum marker for fetal DS.
MATERIALS AND METHODS:
P was quantified in first-trimester maternal serum from 42 DS, six trisomy 18 and two trisomy 13 pregnancies and 115 controls. Log-regression of P versus gestational age in days was used to convert P concentrations into multiples of the median (MoM).
RESULTS:
The P concentrations in controls increased with gestational age (p = 9.5 x 10(-7)). The log10MoM P distribution in DS pregnancies was not significantly different from that in controls. However, from day 58-67, the log10MoM P was elevated in DS pregnancies (n = 10) with a mean (SD) of 0.1040 (0.0956), compared to a mean (SD) of - 0.0109 (0.1661) in controls (n = 24) (p = 0.05). Five out of six trisomy 18 and both trisomy 13 pregnancies had a P MoM < 1.
CONCLUSION:
P is not a useful marker for DS in first trimester, except perhaps in a narrow gestational age window from day 58 to 67. P is a trisomy 18/13 marker.
AuthorsMichael Christiansen, Tina Lindvig Sørensen, Severin Olesen Larsen, Bent Nørgaard-Pedersen
JournalPrenatal diagnosis (Prenat Diagn) Vol. 28 Issue 4 Pg. 319-22 (Apr 2008) ISSN: 0197-3851 [Print] England
PMID18317998 (Publication Type: Evaluation Study, Journal Article)
CopyrightCopyright (c) 2008 John Wiley & Sons, Ltd.
Chemical References
  • Biomarkers
  • Progesterone
Topics
  • Adult
  • Aneuploidy
  • Biomarkers (blood)
  • Case-Control Studies
  • Down Syndrome (blood, diagnosis)
  • Female
  • Humans
  • Mothers
  • Pregnancy
  • Pregnancy Complications (blood, genetics)
  • Pregnancy Trimester, First (blood)
  • Prenatal Diagnosis (methods)
  • Progesterone (blood)

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