Abstract | BACKGROUND: MATERIALS AND METHODS: P was quantified in first-trimester maternal serum from 42 DS, six trisomy 18 and two trisomy 13 pregnancies and 115 controls. Log-regression of P versus gestational age in days was used to convert P concentrations into multiples of the median (MoM). RESULTS: The P concentrations in controls increased with gestational age (p = 9.5 x 10(-7)). The log10MoM P distribution in DS pregnancies was not significantly different from that in controls. However, from day 58-67, the log10MoM P was elevated in DS pregnancies (n = 10) with a mean (SD) of 0.1040 (0.0956), compared to a mean (SD) of - 0.0109 (0.1661) in controls (n = 24) (p = 0.05). Five out of six trisomy 18 and both trisomy 13 pregnancies had a P MoM < 1. CONCLUSION: P is not a useful marker for DS in first trimester, except perhaps in a narrow gestational age window from day 58 to 67. P is a trisomy 18/13 marker.
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Authors | Michael Christiansen, Tina Lindvig Sørensen, Severin Olesen Larsen, Bent Nørgaard-Pedersen |
Journal | Prenatal diagnosis
(Prenat Diagn)
Vol. 28
Issue 4
Pg. 319-22
(Apr 2008)
ISSN: 0197-3851 [Print] England |
PMID | 18317998
(Publication Type: Evaluation Study, Journal Article)
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Copyright | Copyright (c) 2008 John Wiley & Sons, Ltd. |
Chemical References |
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Topics |
- Adult
- Aneuploidy
- Biomarkers
(blood)
- Case-Control Studies
- Down Syndrome
(blood, diagnosis)
- Female
- Humans
- Mothers
- Pregnancy
- Pregnancy Complications
(blood, genetics)
- Pregnancy Trimester, First
(blood)
- Prenatal Diagnosis
(methods)
- Progesterone
(blood)
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