Diagnostic value of CSF biomarker profile in frontotemporal lobar degeneration.

• Abstract: BACKGROUND: Cerebrospinal fluid (CSF) biomarkers have been increasingly studied in dementia clinical and differential diagnosis. METHODS: We assessed levels of total tau protein (tauT), tau phosphorylated at threonine 181 (tau P-181), and beta-amyloid1-42 (A beta 42) in 34 patients with frontotemporal lobar degeneration (FTLD), 76 Alzheimer disease (AD) cases, and 93 controls (CTRL). Double sandwich enzyme-linked immunosorbent assays (Innogenetics) were used for measurements. RESULTS: Total tau was significantly increased and A beta 42 decreased in FTLD and AD patients as compared with CTRL. CSF tau P-181 levels were significantly increased only in AD. The tauT/A beta 42 ratio successfully discriminated FTLD from CTRL with a 86.7% specificity and 80.6% sensitivity, whereas the tauT alone was more specific (95.7%) but less sensitive (64.75%). For the discrimination of FTLD from AD, tauT/A beta 42 ratio was better (90.3% sensitivity and 64.5% specificity) compared with the other biomarkers alone or in combination, whereas tau P-181 was less sensitive but more specific (68.4% and 85.7%, respectively). Subtype analysis revealed that the most AD-like profile of biomarkers were observed in FTLD with motor neuron signs, whereas the most non-AD profile were observed in patients with primary progressive aphasia. CONCLUSIONS: Combined analysis of CSF biomarkers may be useful for the best possible antemortem discrimination of FTLD from AD.
• Authors: Elisabeth Kapaki, George P Paraskevas, Sokratis G Papageorgiou, Anastasios Bonakis, Nikolaos Kalfakis, Ioannis Zalonis, Demetris Vassilopoulos (Affiliation: Department of Neurology, School of Medicine, Athens National University, Eginition Hospital, Athens, Greece. ekapaki at med.uoa.gr)
• Journal: Alzheimer disease and associated disorders (Alzheimer Dis Assoc Disord) 2008 Jan-Mar Vol. 22 Issue 1 Pg. 47-53 ISSN: 0893-0341 [Print] United States
• PMID: 18317246 (Publication Type: Journal Article)

Chemical References

• Amyloid beta-Protein
• Biological Markers
• tau Proteins

Topics

• Aged
• Alzheimer Disease (cerebrospinal fluid)
• Amyloid beta-Protein (cerebrospinal fluid)
• Biological Markers (cerebrospinal fluid)
• Dementia (cerebrospinal fluid)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Middle Aged
• ROC Curve
• Sensitivity and Specificity
• tau Proteins (cerebrospinal fluid)