Abstract | BACKGROUND: MATERIALS AND METHODS: Prospective correlates included measurements of pretreatment plasma VEGF, as well as pretreatment and week 7, bFGF, ICAM, and E-selectin. Low and high levels were defined as less than or equal to or more than the median. RESULTS:
E-selectin (P < 0.0001) showed a decrease and bFGF showed an increase (P = 0.004) from baseline at week 7, which were similar in both arms. Baseline ICAM showed significant associations with response and survival in both groups. Patients with low baseline ICAM had a higher response rate (32% versus 14%; P = 0.02), better overall survival (P = 0.00005), and better 1-year survival (65% versus 25%) than those with high ICAM, respectively, regardless of treatment arm. Patients with high VEGF levels were more likely to respond to BPC compared with PC, but this was not predictive of survival. The results also suggest a benefit from bevacizumab for patients with low baseline ICAM levels (53% reduction in the progression-free survival hazard rate). CONCLUSIONS: In this study, baseline ICAM levels were prognostic for survival and predictive of response to chemotherapy with or without bevacizumab. VEGF levels were predictive of response to bevacizumab but not survival.
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Authors | Afshin Dowlati, Robert Gray, Alan B Sandler, Joan H Schiller, David H Johnson |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 14
Issue 5
Pg. 1407-12
(Mar 01 2008)
ISSN: 1078-0432 [Print] United States |
PMID | 18316562
(Publication Type: Clinical Trial, Phase II, Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- E-Selectin
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Fibroblast Growth Factor 2
- Intercellular Adhesion Molecule-1
- Bevacizumab
- Carboplatin
- Paclitaxel
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Topics |
- Aged
- Antibodies, Monoclonal
(administration & dosage)
- Antibodies, Monoclonal, Humanized
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bevacizumab
- Carboplatin
(administration & dosage)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, metabolism, pathology)
- Chemotherapy, Adjuvant
- Disease-Free Survival
- E-Selectin
(metabolism)
- Female
- Fibroblast Growth Factor 2
(metabolism)
- Humans
- Intercellular Adhesion Molecule-1
(metabolism)
- Lung Neoplasms
(drug therapy, metabolism, pathology)
- Male
- Paclitaxel
(administration & dosage)
- Prospective Studies
- Survival Rate
- Vascular Endothelial Growth Factor A
(metabolism)
|