[Allogeneic peripheral blood hematopoietic stem cell transplantation for post-operatively treating acute non-lymphocytic leukemia patient complicated with renal cell carcinoma: one case report].

Abstract

The aim of this study was to evaluate the safety and efficacy of allogeneic hematopoietic peripheral blood stem cell transplantation (allo-PBHSCT) for post-operative therapy of acute non-lymphocytic leukemia (ANLL) patient complicated with renal cell carcinoma (RCC). One ANLL patient complicated with RCC underwent an myeloablative HLA-identical relative allo-PBHSCT after RCC operation. The conditioning regimen consisted of total body irradiation, cyclophosphamide and cytarabine. Graft versus host disease (GVHD) prophylaxis regimen composed of cyclosporine A, myco-phenolate mofetil and short course of methotrexate. The results indicated that the patient achieved engraftment 16 days after transplantation with full donor-type chimerism detected by STR-PCR at 30 and 100 days after transplantation. No acute or chronic GVHD and any severe complication developed. As of March 2007, the patient remains without disease at follow-up of 44 months. In conclusion, allo-HSCT procedure is feasible and effective for post-operative therapy of ANLL patient complicated with RCC without severe toxicity.

• Authors: Hai-Yan Zhu, Wan-Ming DA, Chun-Ji Gao, Xiao-Ping Han, Shu-Hong Wang, Yu Jing, Jian Bo, Hai-jie Jin, Meng Li
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 16 Issue 1 Pg. 203-6 (Feb 2008) ISSN: 1009-2137 [Print] China
• PMID: 18315932 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Carcinoma, Renal Cell (surgery, therapy)
• Graft vs Host Disease (prevention & control)
• Humans
• Kidney Neoplasms (surgery, therapy)
• Leukemia, Myeloid, Acute (therapy)
• Male
• Neoplasms, Multiple Primary (therapy)
• Peripheral Blood Stem Cell Transplantation
• Postoperative Period
• Transplantation, Homologous