Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apnea.

Abstract

BACKGROUND:

Pediatric OSA is associated with substantial morbidity in cognitive function. However, for any given OSA severity level, altered cognitive performance may or may not be present. Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity.

METHODS:

Consecutive habitually snoring and non-snoring children ages 5-7 years were recruited from the community, and underwent overnight polysomnography, and neurocognitive testing and a blood draw the next morning. Snoring children were divided into OSA or no OSA, and OSA children were further subdivided into those with >=2 abnormal cognitive subtests and into those with normal cognitive scores. Plasma levels of IGF-1 were also measured using ELISA.

RESULTS:

Among snoring children without OSA, circulating IGF-1 was 910 +/- 110 pg/mL compared with 1070 +/- 240 pg/mL in those with OSA (p<0.01). However, IGF-1 was 540 +/- 70 pg/mL in children with OSA and cognitive deficits, compared to 1370 +/- 170 microg/L in children with OSA and normal cognitive scores (p<0.001).

CONCLUSIONS:

IGF-1 levels are higher in children with OSA, particularly in those who do not manifest neurocognitive deficits, suggesting that the magnitude of the IGF-1 response elicited by OSA may play a significant protective role against the neurocognitive dysfunction associated with OSA.

• Authors: David Gozal, Oscar Sans Capdevila, Valerie McLaughlin Crabtree, Laura D Serpero, Lisa A Witcher, Leila Kheirandish-Gozal
• Journal: Sleep medicine (Sleep Med) Vol. 10 Issue 2 Pg. 167-73 (Feb 2009) ISSN: 1389-9457 [Print] Netherlands
• PMID: 18314384 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Insulin-Like Growth Factor I

Topics

• Body Mass Index
• Case-Control Studies
• Child
• Child, Preschool
• Cognition Disorders (blood, complications)
• Female
• Humans
• Insulin-Like Growth Factor I (metabolism)
• Male
• Neuropsychological Tests
• Polysomnography
• Risk Factors
• Sleep Apnea, Obstructive (blood, complications, psychology)
• Snoring (blood, complications, psychology)