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Complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing VP2 from FPV.

Abstract
Feline panleukopenia virus (FPV) is an important infectious pathogen of all members of the family Felidae. Here, we describe construction of a replication-competent recombinant canine adenovirus type 2 (CAV-2) expressing the VP2 protein of FPV (CAV-2-VP2) by transfection of MDCK cells with recombinant CAV-2 genome carrying a VP2 expression cassette. Ten 3-month-old cats were vaccinated with the recombinant virus with two boosters at 15-day intervals. All cats developed neutralizing antibodies of titers 1:16-1:32 by day 15 post-primary vaccination, increasing to 1:64-1:128 by day 45. Examination for clinical signs and viral presence, and total white blood cell counts in peripheral blood following FPV challenge, showed that all were completely protected. This recombinant virus appears to provide an effective alternative to attenuated and inactivated vaccines in immunizing cats against feline panleukopenia.
AuthorsSongtao Yang, Xianzhu Xia, Jun Qiao, Quan Liu, Shuang Chang, Zhijing Xie, Huiyan Ju, Xiaohuan Zou, Yuwei Gao
JournalVaccine (Vaccine) Vol. 26 Issue 11 Pg. 1482-7 (Mar 10 2008) ISSN: 0264-410X [Print] Netherlands
PMID18313810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • Vaccines, Synthetic
  • Viral Vaccines
Topics
  • Adenoviruses, Canine (genetics, immunology)
  • Animals
  • Antibodies, Viral (biosynthesis, immunology)
  • Cats
  • Cell Proliferation (drug effects)
  • Dogs
  • Feline Panleukopenia (immunology, prevention & control, virology)
  • Feline Panleukopenia Virus (genetics, immunology)
  • Female
  • Immunity, Cellular (drug effects)
  • Lymphocytes (drug effects, immunology)
  • Male
  • Neutralization Tests
  • Vaccination
  • Vaccines, Synthetic (immunology, therapeutic use)
  • Viral Vaccines (immunology, therapeutic use)

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