2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: a novel class of antitumor agents.

Abstract	A series of 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines were synthesized and evaluated for their cytotoxic activity in vitro against five human cancer cell lines (human lung carcinoma cell line: A549, human leukemia cell lines: K562 and Molt-4, human prostate cancer cell line: PC-3, human breast carcinoma cell line: MDA-MB-231). Most of these compounds show potent activity against these tumor cell lines, especially against the A549 cell line. The cell cycle analysis was also studied by flow cytometry measurement on A549 cell line.
Authors	Yandong Zhang, Zhe Chen, Yijia Lou, Yongping Yu
Journal	European journal of medicinal chemistry (Eur J Med Chem) Vol. 44 Issue 1 Pg. 448-52 (Jan 2009) ISSN: 1768-3254 [Electronic] France
PMID	18313807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Quinazolines
Topics	Antineoplastic Agents (chemical synthesis, pharmacology) Cell Cycle (drug effects) Cell Line, Tumor Cell Survival (drug effects) Drug Screening Assays, Antitumor Female Humans Male Quinazolines (chemical synthesis, pharmacology)

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