Effect of retinoids and carotenoids on prostaglandin formation by oral squamous carcinoma cells.

Abstract

Several studies have correlated the excessive production of prostaglandins (PGs) with tumor promotion and the suppression of the immune response. Inhibition of PGs by pharmacological agents has been demonstrated to enhance immunocompetence, and to suppress growth of tumors in animals and humans. In this study we examined the effect of retinol (I), all-trans-retinoic acid (II), N-(4-Hydroxyphenyl) retinamide (N-4-HPR) (III), canthaxanthin (CTX) (IV), and beta-carotene (beta-CT) (V) on the bioconversion of 14C-arachidonic acid (AA) to PGE2 by squamous carcinoma cells of the tongue, SCC-25. Agents (I), (II), (III), (IV) inhibited while (V) stimulated PGE2 formation in a dose related manner. N-4-HPR was the most potent inhibitor of PGE2 synthesis. The data suggest that certain retinoids and carotenoids have the potential of inhibition of PG synthesis by oral squamous carcinoma cells. Inhibitory effects such as those described here and antioxidant properties might in part contribute to the antiinflammatory and anticarcinogenic activity of retinoids in vivo.

• Authors: T M ElAttar, H S Lin
• Journal: Prostaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids) Vol. 43 Issue 3 Pg. 175-8 (Jul 1991) ISSN: 0952-3278 [Print] Scotland
• PMID: 1831272 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Prostaglandins
• Retinoids
• beta Carotene
• Vitamin A
• Fenretinide
• Carotenoids
• Canthaxanthin
• Tretinoin
• Indomethacin

Topics

• Canthaxanthin
• Carcinoma, Squamous Cell (metabolism)
• Carotenoids (analogs & derivatives, pharmacology)
• Chromatography, Thin Layer
• Fenretinide
• Humans
• Indomethacin (pharmacology)
• Prostaglandins (biosynthesis)
• Retinoids (pharmacology)
• Tongue Neoplasms (metabolism)
• Tretinoin (analogs & derivatives, pharmacology)
• Tumor Cells, Cultured
• Vitamin A (pharmacology)
• beta Carotene