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11beta-hydroxysteroid dehydrogenase type 1 inhibitors for metabolic syndrome.

Abstract
The metabolic syndrome is a constellation of interrelated metabolic risk factors that appear to promote the development of diabetes and cardiovascular disease. These risk factors include abdominal obesity, insulin resistance, hypertension and dyslipidemia. 11beta-Hydroxysteroid dehydrogenase (11beta-HSD) catalyzes the interconversion of glucocorticoids through the activity of two isozymes: type 1 (11beta-HSD1) and type 2 (11beta-HSD2). 11beta-HSD1 converts inactive glucocorticoid to the active form, whereas 11beta-HSD2 converts active glucocorticoid to the inactive form. It is well established that reduced 11beta-HSD2 activity causes hypertension and electrolyte abnormalities. More recently, the pathophysiological role of 11beta-HSD1 has been explored and studies suggest that increased 11beta-HSD1 activity within target tissues may promote insulin resistance, obesity, hypertension and dyslipidemia. This review will discuss the evidence that inhibition of 11beta-HSD1 may be therapeutic in the treatment of the metabolic syndrome.
AuthorsChristine G Schnackenberg
JournalCurrent opinion in investigational drugs (London, England : 2000) (Curr Opin Investig Drugs) Vol. 9 Issue 3 Pg. 295-300 (Mar 2008) ISSN: 1472-4472 [Print] England
PMID18311666 (Publication Type: Journal Article, Review)
Chemical References
  • Enzyme Inhibitors
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1
  • Glucose
Topics
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 (antagonists & inhibitors)
  • Animals
  • Enzyme Inhibitors (therapeutic use)
  • Glucose (metabolism)
  • Homeostasis (drug effects)
  • Humans
  • Hypertension (drug therapy, enzymology, physiopathology)
  • Lipid Metabolism (drug effects)
  • Metabolic Syndrome (drug therapy, enzymology)
  • Obesity (enzymology)

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