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Serum soluble CD163 and interleukin-6 levels in women with ovarian endometriomas.

AbstractBACKGROUND:
CD163 is a hemoglobin scavenger receptor exclusively expressed in the monocyte-macrophage system and its soluble form (sCD163) has not yet been studied as a serum marker in women with endometriosis. The purpose of this study was to evaluate whether serum levels of sCD163 and interleukin-6 (IL-6) could be possible markers for ovarian endometriomas discriminating adnexal benign cystic tumors.
METHODS:
The concentrations of sCD163 and IL-6 were determined using commercial ELISA kits in frozen sera collected from 95 women prior to surgery for adnexal benign cystic tumors: 44 with ovarian endometriomas, 24 with mature cystic teratomas, 10 with mucinous cystadenomas, 8 with serous cystadenomas and 9 with parovarian cysts. Serum levels of CA-125 were also recorded preoperatively. The volume of cysts was evaluated in women with ovarian endometriomas.
RESULTS:
The serum levels of sCD163 and IL-6 were not significantly different among the women with various adnexal benign cystic tumors. In patients with endometriomas (n = 44), the levels were similar to those with nonendometriotic benign cystic tumors (n = 51): 3,431.7 +/- 343.9 vs. 3,231.0 +/- 391.7 ng/ml for sCD163 and 5.3 +/- 0.9 vs. 12.9 +/- 4.0 pg/ml for IL-6 (mean +/- SEM). No correlation was noted between serum levels of two markers with volume of endometriomas.
CONCLUSION:
Our findings suggest that serum levels of sCD163 as well as IL-6 are not useful markers for ovarian endometriomas.
AuthorsByung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Shin Yong Moon
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 66 Issue 1 Pg. 47-52 ( 2008) ISSN: 1423-002X [Electronic] Switzerland
PMID18311079 (Publication Type: Journal Article)
CopyrightCopyright 2008 S. Karger AG, Basel.
Chemical References
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Biomarkers
  • CA-125 Antigen
  • CD163 antigen
  • Interleukin-16
  • Receptors, Cell Surface
Topics
  • Adult
  • Antigens, CD (blood)
  • Antigens, Differentiation, Myelomonocytic (blood)
  • Biomarkers (blood)
  • CA-125 Antigen (blood)
  • Endometriosis (blood)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-16 (blood)
  • Middle Aged
  • Ovarian Diseases (blood)
  • Receptors, Cell Surface (blood)

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