Abstract |
In the course of isolating preventive agents from sepsis based on the in vivo assay model from the EtOAc extract of the roots of Saururus chinensis, twelve lignans, sarisan (1), erythro-austrobailignan-6 (2), meso-dihydroguaiaretic acid (3), saucerneol B (4), manassantin B (5), manassantin A (6), rel-(8R,8'R)-dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan (7), (+)-saururinone (8), sauchinone (9), sauchinone B (10), nectandrin B (11) and machilin D (12), were isolated. Compounds 9 and 10, at a dose of 10 mg/kg, increased survival rates to 80% from 20% for the control experiment, and decreased the plasma levels of tumor necrosis factor-alpha ( TNF-alpha) and alanine aminotransferase (ALT) activity in mice administered LPS/D-GalN.
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Authors | Chang-Seob Seo, Yeun-Kyung Lee, Young-Jin Kim, Jun-Sub Jung, Yurngdong Jahng, Hyun-Wook Chang, Dong-Keun Song, Jong-Keun Son |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 31
Issue 3
Pg. 523-6
(Mar 2008)
ISSN: 0918-6158 [Print] Japan |
PMID | 18310923
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Lignans
- Lipopolysaccharides
- Plant Extracts
- lipopolysaccharide, E coli O55-B5
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Cytokines
(blood, immunology)
- Disease Models, Animal
- Lignans
(isolation & purification, therapeutic use)
- Lipopolysaccharides
(toxicity)
- Liver
(drug effects, enzymology)
- Male
- Mice
- Mice, Inbred ICR
- Plant Extracts
(chemistry)
- Plant Roots
(chemistry)
- Saururaceae
(chemistry)
- Sepsis
(drug therapy, enzymology, immunology)
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