Results of 101 aneurysms treated with polyglycolic/polylactic acid microfilament nexus coils compared with historical controls treated with standard coils.

Polyglycolic/polylactic acid (PGLA) addition to bare platinum coils is intended to reduce the reopening rate of coiled intracranial aneurysms. Nexus coils are standard complex platinum coils with interwoven PGLA microfilament threads. We present the clinical results of 101 intracranial aneurysms treated with Nexus coils.
Results of coiling of 101 aneurysms treated with Nexus coils were compared with our results of coiling of 120 aneurysms with Guglielmi detachable coils (GDC 10) and 115 with Trufill coils treated between May 2003 and December 2004 with the same treatment protocol. Rate of complications, mean aneurysmal volume, packing attenuation, incomplete aneurysmal occlusion at 6 months, and rates of retreatment were compared.
Initial occlusion in aneurysms treated with Nexus coils was (near) complete in 97 aneurysms and incomplete in 4 aneurysms. There were no permanent procedural complications (0/95 patients, 0%; 97.5% CI, 0.0% to 3.3%). Mean aneurysmal volume was 180.2 mm(3) (range, 5-1624 mm(3)). Mean packing was 19.4% (range, 7.5% to 38.9%). Six months' angiographic follow-up in 87 of 101 aneurysms showed incomplete occlusion in 14 (16%), and 12 (14%) of those had additional coiling. Mean packing of 19.4% of Nexus coils was significantly lower than 22.9% for GDC 10 and 29.7% for Trufill coils. Other clinical results were not significantly different.
In this series, PGLA microfilament Nexus coils were safe to use with clinical results comparable with those of standard platinum coils. This study gives additional evidence of the lack of beneficial effect of PGLA addition to reduce the reopening rate of coiled intracranial aneurysms.
AuthorsW J van Rooij, A N de Gast, M Sluzewski
JournalAJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) Vol. 29 Issue 5 Pg. 991-6 (May 2008) ISSN: 1936-959X [Electronic] United States
PMID18310232 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • polylactic acid-polyglycolic acid copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Platinum
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Embolization, Therapeutic (instrumentation, methods)
  • Equipment Failure Analysis
  • Female
  • Humans
  • Intracranial Aneurysm (therapy)
  • Lactic Acid
  • Male
  • Middle Aged
  • Platinum
  • Polyglycolic Acid
  • Treatment Outcome

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