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Sildenafil as a pulmonary vasodilator after repair of congenital heart disease.

Abstract
We describe successful use of enteral sildenafil following surgery for congenital heart disease in three cases. One infant after repair of ventricular septal defect and aortic coarctation had pulmonary hypertension non-responsive to nitric oxide, another infant and 3.5 year child following palliative surgery for congenital heart disease with univentricular physiology were treated with inhaled nitric oxide and had severe systemic desaturations associated with endotracheal suctioning. Therapy with sildenafil reduced pulmonary arterial pressure, prevented episodes of arterial desaturations and allowed weaning from nitric oxide (Ref. 7). Full Text (Free, PDF) www.bmj.sk
AuthorsL Kovacikova, M Zahorec, M Nosal
JournalBratislavske lekarske listy (Bratisl Lek Listy) Vol. 108 Issue 10-11 Pg. 453-4 ( 2007) ISSN: 0006-9248 [Print] Slovakia
PMID18306725 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Phosphodiesterase Inhibitors
  • Piperazines
  • Purines
  • Sulfones
  • Vasodilator Agents
  • Sildenafil Citrate
Topics
  • Female
  • Heart Defects, Congenital (surgery)
  • Humans
  • Hypertension, Pulmonary (drug therapy, etiology, physiopathology)
  • Infant
  • Phosphodiesterase Inhibitors (therapeutic use)
  • Piperazines (therapeutic use)
  • Postoperative Complications
  • Purines (therapeutic use)
  • Sildenafil Citrate
  • Sulfones (therapeutic use)
  • Vascular Resistance
  • Vasodilator Agents (therapeutic use)

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