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[Genetically confirmed nosocomial transmission of staphylococcal scalded skin syndrome between two infants in the neonatal intensive care unit].

Abstract
We report two consecutive cases of staphylococcal scalded skin syndrome (SSSS) in our neonatal intensive care unit (NICU). Methicillin-resistant Staphylococcus aureus (MRSA) was isolated from skin swabs. An epidemiological survey conducted on the NICU staff, isolated MRSA from nasal swabs of three personnel. Gene analysis of these five isolates using pulsed-field gel electrophoresis (PFGE) of the bacterial genome and polymerase chain reaction (PCR) for a panel of toxin genes encoded two patient-derived isolates of exfoliative toxin B (ETB) considered to be identical based on the spectrum of toxin genes encoded and PFGE patterns. Three staff-derived isolates did not, however, encode ETB and showed different repertoires of toxin genes and PFGE patterns from those of the two patient-derived isolates. Nasal application of mupirocin to all carriers successfully eradicated MRSA. Horizontal transmission of ETB-producing MRSA between the two patients in the NICU was confirmed, but no NICU personnel carried the same isolate. We therefore wish to emphasize the importance of strict standard and contact precautionary measures and the monitoring of MRSA in the NICU, together with the usefulness of gene analysis using PFGE and PCR as epidemiological tools.
AuthorsMasanori Egashira, Masato Tagawa, Yoichi Hirakata, Motoyuki Sugai, Hiroyuki Moriuchi
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases (Kansenshogaku Zasshi) Vol. 82 Issue 1 Pg. 34-7 (Jan 2008) ISSN: 0387-5911 [Print] Japan
PMID18306677 (Publication Type: English Abstract, Journal Article)
Topics
  • Cross Infection (transmission)
  • Electrophoresis, Gel, Pulsed-Field
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases (microbiology)
  • Intensive Care Units, Neonatal
  • Polymerase Chain Reaction
  • Staphylococcal Scalded Skin Syndrome (transmission)
  • Staphylococcus aureus (genetics)

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