Progress in the studies on rutaecarpine.

Abstract

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. Recent progress in the studies on the isolation, synthesis, structure-activity relationship studies, biological activities and metabolism of rutaecarpine are reviewed.

• Authors: Seung Ho Lee, Jong-Keun Son, Byeong Seon Jeong, Tae-Cheon Jeong, Hyeon Wook Chang, Eung-Seok Lee, Yurngdong Jahng
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 13 Issue 2 Pg. 272-300 (Feb 06 2008) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 18305418 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Indole Alkaloids
• Quinazolines
• rutecarpine

Topics

• Animals
• Humans
• Indole Alkaloids (chemical synthesis, chemistry, metabolism, pharmacology)
• Quinazolines (chemical synthesis, chemistry, metabolism, pharmacology)