New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm.

Three new compounds: 2R,3R-pterosin L 3-O-beta-D-glucopyranoside (1), beta-D-xylopyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (2) and 4-O-benzoyl-beta-D-xylo-pyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (3), together with nine known compounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated from natural sources for the first time. The structures of all isolated compounds were determined on the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) show cytotoxicity against HL 60 cells (human leukemia) with the IC(50) values of 3.7 and 8.7 microg/mL, respectively.
AuthorsYung-Husan Chen, Fang-Rong Chang, Mei-Chin Lu, Pei-Wen Hsieh, Ming-Jiuan Wu, Ying-Chi Du, Yang-Chang Wu
JournalMolecules (Basel, Switzerland) (Molecules) Vol. 13 Issue 2 Pg. 255-66 ( 2008) ISSN: 1420-3049 [Electronic] Switzerland
PMID18305416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carbon Isotopes
  • Glucosides
  • Indans
  • Protons
  • Sesquiterpenes
  • pterosin
  • pterosin B
  • Carbon Isotopes
  • Cell Death (drug effects)
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Glucosides (chemistry, isolation & purification, pharmacology)
  • Humans
  • Indans (chemistry, isolation & purification)
  • Magnetic Resonance Spectroscopy
  • Protons
  • Pteris (chemistry)
  • Sesquiterpenes (chemistry, isolation & purification)

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