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Tadalafil is efficacious and well tolerated in the treatment of erectile dysfunction (ED) in men over 65 years of age: results from Multiple Observations in Men with ED in National Tadalafil Study in the United States.

AbstractINTRODUCTION:
Erectile dysfunction is increasingly common with advancing age, yet sexual activity and intimacy are important to elderly men.
AIM:
To assess the efficacy and tolerability of tadalafil in men over the age of 65 years.
METHOD:
In this multicenter open-label study, 188 men (mean age = 71.6 years) who were over age 65 and did not have diabetes mellitus or clinical depression received tadalafil 20 mg, taken on demand, for up to 12 weeks.
MAIN OUTCOME MEASURES:
Efficacy was assessed using the International Index of Erectile Function (IIEF) and Sexual Encounter Profile (SEP). Psychosocial outcomes were evaluated using the Psychological and Interpersonal Relationship Scale (PAIRS).
RESULTS:
Tadalafil treatment significantly improved all domains of the IIEF from baseline, including the erectile function (EF) domain (change = 8.8, end point = 21.6; P < 0.001). Mean per-patient percentage of "yes" responses to SEP questions concerning successful penetration (SEP2; change = 33.5%, end point = 73.5%; P < 0.001) and successful intercourse (SEP3; change = 39.6%, end point = 59.6%; P < 0.001) also improved significantly from baseline. Forty percent of the patients with baseline EF scores < 26 had normal EF (IIEF-EF domain scores > or = 26) at end point, and 81% reported improved erections in the Global Assessment Questionnaire. At least 56% of attempts at sexual intercourse were successfully completed (SEP3) at all time intervals up to 36 hours after tadalafil administration. The patients also experienced significant improvement in both the sexual self-confidence and spontaneity domains of the PAIRS. Tadalafil was well tolerated, with < 5% of the patients discontinuing because of adverse events.
CONCLUSION:
Tadalafil 20 mg was effective and well tolerated in elderly men with ED.
AuthorsIra D Sharlip, Bryan P Shumaker, Lawrence S Hakim, Evan Goldfischer, Fanni Natanegara, David G Wong
JournalThe journal of sexual medicine (J Sex Med) Vol. 5 Issue 3 Pg. 716-25 (Mar 2008) ISSN: 1743-6109 [Electronic] Netherlands
PMID18304286 (Publication Type: Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Carbolines
  • Phosphodiesterase Inhibitors
  • Tadalafil
Topics
  • Aged
  • Aged, 80 and over
  • Carbolines (administration & dosage)
  • Dose-Response Relationship, Drug
  • Erectile Dysfunction (drug therapy, psychology)
  • Humans
  • Male
  • Patient Satisfaction (statistics & numerical data)
  • Penile Erection (drug effects)
  • Phosphodiesterase Inhibitors (administration & dosage)
  • Research Design
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Tadalafil
  • Treatment Outcome

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