[Beta-ionone induced apoptosis in SGC-7901 cells].

Abstract

OBJECTIVE:

In order to determine the inhibitory effects and apoptosis of beta-ionone in human gastric carcinoma SGC-7901 cell line and its possible mechanism.

METHODS:

The assays of the curves of cell proliferation, cell mitosis, Hoechst 33258 dye stained, emission electronic microscope, and western blotting were employed.

RESULTS:

Beta-ionone could inhibit the growth and cell mitosis in SGC-7901 cells. The EC50 value was (174.93 +/- 12.79) micromol/L. Morphology of apoptosis was observed by Hoechst 33258 dye stained and emission electronic microscope. The fragmentation of activated caspase-3 was induced and expression of Erkl/2 protein was decreased in SGC-7901 cells treated with different levels of beta-ionone.

CONCLUSION:

Thus beta-ionone could induce apoptosis in SGC-7901 cells and exactly mechanism needed further to be studied.

• Authors: Xiangrong Sun, Jiaren Liu, Wenguang Sun, Xuanle Tang
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 36 Issue 6 Pg. 667-70 (Nov 2007) ISSN: 1000-8020 [Print] China
• PMID: 18303623 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Norisoprenoids
• beta-ionone
• Mitogen-Activated Protein Kinase 3
• CASP3 protein, human
• Caspase 3

Topics

• Adenocarcinoma (pathology)
• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis (drug effects)
• Caspase 3 (metabolism)
• Cell Line, Tumor
• Humans
• Mitogen-Activated Protein Kinase 3 (metabolism)
• Norisoprenoids (pharmacology)
• Stomach Neoplasms (pathology)