Fixed drug eruption from pamabrom.

Abstract

A young woman presented with recurrent skin lesions that were predominantly perioral. Fixed drug reaction was diagnosed based on her history of intermittent ingestion of Pamprin, a common menstrual symptom reliever, and characteristic erythematous, pigmented, edematous patches. After oral challenge with two of the three ingredients in Pamprin, a diagnosis of fixed drug reaction to pamabrom was made. Pamabrom is a mild diuretic present in several over-the-counter and prescription menstrual symptom relievers. This is the first reported case of fixed drug reaction to pamabrom.

• Authors: S Nedorost, J S Taylor, C Camisa, K J Tomecki, T Helm, W J Durkin
• Journal: Cleveland Clinic journal of medicine (Cleve Clin J Med) 1991 Jan-Feb Vol. 58 Issue 1 Pg. 33-4 ISSN: 0891-1150 [Print] United States
• PMID: 1829985 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• Propanolamines
• Theophylline
• pamabrom

Topics

• Adult
• Drug Combinations
• Drug Eruptions (etiology)
• Female
• Humans
• Menstruation (drug effects)
• Propanolamines (adverse effects, therapeutic use)
• Skin Ulcer (chemically induced)
• Theophylline (adverse effects, analogs & derivatives, therapeutic use)