Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.

Abstract

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

• Authors: Hiroshi Kakeya, Yoshitsugu Miyazaki, Hisato Senda, Tsutomu Kobayashi, Masafumi Seki, Koichi Izumikawa, Yoshihiro Yamamoto, Kazunori Yanagihara, Takayoshi Tashiro, Shigeru Kohno
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 5 Pg. 1871-2 (May 2008) ISSN: 1098-6596 [Electronic] United States
• PMID: 18299408 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Polyenes
• SPA S 843

Topics

• Animals
• Antifungal Agents (pharmacology, therapeutic use)
• Brain (drug effects, microbiology)
• Cryptococcosis (drug therapy, microbiology)
• Cryptococcus neoformans (drug effects)
• Disease Models, Animal
• Female
• Mice
• Mice, Inbred BALB C
• Polyenes (pharmacology, therapeutic use)